In a shallow dish, whisk together the flour, paprika, garlic powder, onion powder, 1/2 teaspoon salt, and 1/4 teaspoon black pepper.
Add the chicken and turn to coat both sides. Shake off excess flour.
Melt the butter in a large skillet over medium-high heat. When the butter is bubbly, add the chicken and cook until golden brown on both sides. If necessary, work in batches to prevent crowding the pan. Return all the chicken to the pan before adding the sauce.
In a small bowl, whisk together the hot sauce, water, and brown sugar. Add the mixture to the pan and bring to a simmer. Simmer for 3 to 5 minutes, until the sauce thickens and reduces, and the chicken is cooked through.